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Updated: May 24, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Acute neuromuscular weakness associated with dengue infection
Harmanjit Singh Hira1, Amandeep Kaur, Anuj Shukla
1Department of Pulmonary Medicine, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Journal of Neurosciences in Rural Practice
|February 21, 2012
Summary
Dengue virus infection can cause acute neuromuscular weakness, often due to hypokalemia. Prompt potassium correction is crucial for recovery in affected dengue patients.
Area of Science:
- Neurology
- Infectious Diseases
- Clinical Medicine
Background:
- Neurological complications are observed in dengue infections.
- The exact cause of these complications, whether neuromuscular disease or electrolyte imbalance, remains unclear.
Purpose of the Study:
- To investigate the causes of acute neuromuscular weakness in hospitalized dengue fever patients.
- To identify specific factors contributing to neurological manifestations in dengue.
Main Methods:
- Study included 12 dengue fever patients with acute neuromuscular weakness.
- Evaluated clinical presentation, serum electrolytes, creatine phosphokinase (CPK), and complete hemogram.
- Two patients underwent nerve conduction velocity (NCV) and electromyography.
Main Results:
- Hypokalemia was present in 10 out of 12 patients.
- One patient had Guillain-Barré syndrome, another had myositis.
- Elevated CPK and SGOT were noted in 8 patients; thrombocytopenia was universal.
Conclusions:
- Dengue virus infection can lead to acute neuromuscular weakness via hypokalemia, myositis, and Guillain-Barré syndrome.
- Hypokalemia should be actively screened for in dengue patients presenting with neuromuscular weakness.
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