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Related Experiment Video

Updated: May 24, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Acute generalized exanthematous pustulosis caused by daptomycin.

Teoh Yee Leng¹, Mark Koh Jean Aan, Michelle Chan

¹Department of Dermatology, Changi General Hospital, Singapore 529889, Singapore.

Annals of Dermatology

|February 21, 2012

Summary

Daptomycin, an antibiotic for resistant infections, can cause acute generalized exanthematous pustulosis (AGEP). This is the first reported case of AGEP linked to daptomycin use.

Keywords:

Acute generalized exanthematous pustulosis Daptomycin

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Last Updated: May 24, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Area of Science:

Dermatology
Infectious Diseases
Pharmacology

Background:

Daptomycin is a lipopeptide antibiotic effective against resistant Gram-positive bacteria.
Acute generalized exanthematous pustulosis (AGEP) is an adverse drug reaction characterized by widespread pustules.
Antibiotics are a common cause of AGEP.

Observation:

A case of AGEP following daptomycin treatment for a skin infection is presented.
The patient developed numerous sterile, nonfollicular pustules.
This reaction occurred despite daptomycin's efficacy against the causative bacteria.

Findings:

This report details the first documented instance of AGEP associated with daptomycin.
The findings highlight a potential, previously unrecognized adverse effect of daptomycin.
The characteristic AGEP morphology was observed.

Implications:

Clinicians should be aware of the potential for daptomycin-induced AGEP.
This case expands the spectrum of known antibiotic-associated dermatological reactions.
Further investigation into daptomycin's potential to trigger AGEP is warranted.