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Acute generalized exanthematous pustulosis caused by daptomycin

Teoh Yee Leng1, Mark Koh Jean Aan, Michelle Chan

  • 1Department of Dermatology, Changi General Hospital, Singapore 529889, Singapore.

Annals of Dermatology
|February 21, 2012
PubMed

Insights

Daptomycin, an antibiotic for resistant infections, can cause acute generalized exanthematous pustulosis (AGEP). This is the first reported case of AGEP linked to daptomycin use.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Daptomycin is a lipopeptide antibiotic effective against resistant Gram-positive bacteria.
  • Acute generalized exanthematous pustulosis (AGEP) is an adverse drug reaction characterized by widespread pustules.
  • Antibiotics are a common cause of AGEP.

Observation:

  • A case of AGEP following daptomycin treatment for a skin infection is presented.
  • The patient developed numerous sterile, nonfollicular pustules.
  • This reaction occurred despite daptomycin's efficacy against the causative bacteria.

Findings:

  • This report details the first documented instance of AGEP associated with daptomycin.
  • The findings highlight a potential, previously unrecognized adverse effect of daptomycin.
  • The characteristic AGEP morphology was observed.

Implications:

  • Clinicians should be aware of the potential for daptomycin-induced AGEP.
  • This case expands the spectrum of known antibiotic-associated dermatological reactions.
  • Further investigation into daptomycin's potential to trigger AGEP is warranted.
Keywords:
Acute generalized exanthematous pustulosisDaptomycin

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