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Updated: May 24, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N'-(3-Eth-oxy-2-hy-droxy-benzyl-idene)-2-hy-droxy-3-methyl-benzohydrazide
Zhao-Fu Zhu1, Li-Juen Shao, Xi-Hai Shen
1Department of Chemistry, Hebei Normal University of Science and Technology, Qinhuangdao 066600, People's Republic of China.
Abstract:
The title compound, C(17)H(18)N(2)O(4), crystallizes with two independent mol-ecules in the asymmetric unit. The two benzene rings in each mol-ecule make dihedral angles of 7.6 (3) and 3.9 (3)°. Intra-molecular O-H⋯N and O-H⋯O hydrogen bonds are present in each mol-ecule. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into chains propagating in [010]. The are also a number of C-H⋯O and π-π inter-actions present [centroid-centroid distances = 3.874 (4) and 3.904 (3) Å], that result in the formation of a three-dimensional network.
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