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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
2,6-Bis(4-chloro-phen-yl)-1,3-dimethyl-piperidin-4-one O-benzyl-oxime
Abstract:
The piperidin-4-one ring in the title compound, C(26)H(26)Cl(2)N(2)O, exists in a chair conformation with equatorial orientations of the methyl and 4-chlorophenyl groups. The C atom bonded to the oxime group is statistically planar (bond-angle sum = 360.0°) although the C-C=N bond angles are very different [117.83 (15) and 127.59 (15)°]. The dihedral angle between the chloro-phenyl rings is 54.75 (4)°. In the crystal, mol-ecules inter-act via van der Waals forces.
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