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Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Radionuclide Testing
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Ischemic colitis secondary to ergotamine use: a case study.

Regina E Rodman1, Thomas D Willson, Mark M Connolly

  • 1Resurrection - St. Joseph Hospital, Department of Surgery, Chicago, Ill., USA.

Case Reports in Gastroenterology
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Ergotamine, a migraine treatment, can cause ischemic colitis, a serious condition involving colon tissue death. This case highlights the importance of considering medication side effects in patients with severe abdominal symptoms.

Keywords:
Dihydroergotamine mesylateErgotamineIschemic colitisVasospasm

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Area of Science:

  • Gastroenterology
  • Neurology
  • Pharmacology

Background:

  • A patient with chronic migraines was admitted for intractable headaches.
  • Treatment involved a multidisciplinary approach in a specialized headache unit.

Observation:

  • On hospital day ten, the patient developed abdominal pain, hypotension, and diarrhea.
  • She was transferred to the ICU for septic shock and metabolic acidosis.

Findings:

  • Bedside colonoscopy revealed diffuse ischemic colitis.
  • Pathology after colon resection confirmed widespread transmural necrosis of the colonic wall.

Implications:

  • This case suggests a potential association between ergotamine use and ischemic colitis.
  • Understanding the pathophysiology of ergotamine is crucial for managing severe migraine treatments.