Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study.

National science review·2022
Same author

Academy of Medicine, Singapore clinical guideline on the use of sedation by non-anaesthesiologists during gastrointestinal endoscopy in the hospital setting.

Annals of the Academy of Medicine, Singapore·2022
Same author

Impact of introduction of an enhanced recovery protocol on the outcomes of laparoscopic liver resections: A propensity-score matched study.

Surgery·2021
Same author

Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma.

Cancers·2021
Same author

Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients.

Journal of Cancer·2021
Same author

Resected pancreatic adenocarcinoma: An Asian institution's experience.

Cancer reports (Hoboken, N.J.)·2021

Related Experiment Videos

Arterio-pancreatic syndrome.

Ser Yee Lee1, Kheng Hong Ng, Mathew George Sebastian

  • 1Department of General Surgery, Singapore General Hospital, Singapore, Republic of Singapore.

Case Reports in Gastroenterology
|February 21, 2012
PubMed
Summary

Acute pancreatitis can rarely cause acute limb ischemia. This case highlights severe bilateral lower limb ischemia requiring amputation, despite pancreatitis resolution.

Area of Science:

  • Gastroenterology
  • Vascular Surgery
  • Critical Care Medicine

Background:

  • Acute pancreatitis, a pancreatic inflammation, can lead to systemic complications affecting multiple organs.
  • While diverse presentations exist, acute limb ischemia is an uncommon manifestation of acute pancreatitis.

Observation:

  • A patient presented with acute pancreatitis that manifested as bilateral lower limb ischemia.
  • The limb ischemia worsened as pancreatitis progressed, ultimately requiring bilateral above-knee amputations.

Findings:

  • Acute pancreatitis can precipitate severe vascular events like acute limb ischemia.
  • The progression of pancreatitis correlated with the worsening of ischemia, despite initial pancreatitis management.

Implications:

Keywords:
Acute limb ischemiaAcute pancreatitisArterio-pancreatic syndrome

Related Experiment Videos

  • This case underscores the critical need to consider pancreatitis in patients with unexplained limb ischemia.
  • Understanding the pathogenesis of pancreatitis-induced vascular complications is crucial for timely intervention and improved patient outcomes.