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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: May 24, 2026

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
10:53

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

Fine-Tuning Oligodendrocyte Development by microRNAs.

Olga Barca-Mayo1, Q Richard Lu

  • 1Department of Developmental Biology, Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center Dallas, TX, USA.

Frontiers in Neuroscience
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are crucial regulators of oligodendrocyte development and central nervous system myelination. Understanding their role offers new therapeutic avenues for demyelinating diseases.

Keywords:
feed-back regulationmiRNAsmyelinationneural cell fateoligodendrocytetranscriptional control

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Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
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Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

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Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Oligodendrocytes are vital for central nervous system (CNS) myelination, essential for neuronal function.
  • Failure in remyelination leads to severe demyelinating diseases.
  • Oligodendrocyte precursors migrate and differentiate, forming complex myelin sheaths.

Purpose of the Study:

  • To review the critical role of microRNAs (miRNAs) in oligodendrocyte development.
  • To discuss the functional links between miRNAs and central myelination regulatory networks.
  • To explore the implications of miRNAs in demyelinating diseases.

Main Methods:

  • Literature review of recent studies on miRNAs and myelination.
  • Analysis of miRNA regulatory networks in oligodendrocyte development.
  • Synthesis of current knowledge on miRNA involvement in demyelinating pathologies.

Main Results:

  • MicroRNAs (miRNAs) are potent posttranscriptional regulators impacting cell biology.
  • Recent research highlights miRNAs' critical roles in oligodendrocyte proliferation, differentiation, and myelin formation.
  • Functional links between miRNAs and central myelination regulatory networks are increasingly understood.

Conclusions:

  • MicroRNAs play a fundamental role in oligodendrocyte development and CNS myelination.
  • Dysregulation of miRNAs is implicated in demyelinating diseases.
  • Further research into miRNA functions may yield novel therapeutic strategies for demyelinating conditions.