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Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
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Astroblastoma with bone invasion.

Suchanda Bhattacharjee1, Aneel Kumar Pulligopu, Megha S Uppin

  • 1Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, India.

Asian Journal of Neurosurgery
|February 21, 2012
PubMed
Summary

Astroblastoma, a rare glial neoplasm, can present as an intra-axial lesion. Complete surgical removal in a pediatric case led to no recurrence at 20 months, highlighting successful management of this unusual tumor.

Keywords:
Astroblastomabone erosionneuroepithelial tumor

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Published on: September 9, 2020

Area of Science:

  • Neuro-oncology
  • Pediatric neurosurgery
  • Pathology of central nervous system tumors

Background:

  • Astroblastoma is a rare primary glial neoplasm of neuroepithelial origin.
  • The World Health Organization (WHO) grading for astroblastoma is not yet established.
  • Understanding the clinical behavior and management of astroblastoma is crucial due to its rarity.

Observation:

  • A 4-year-old child presented with an intra-axial space-occupying lesion.
  • The lesion was diagnosed as an astroblastoma with invasion into the calvarium.
  • Surgical intervention involved complete excision of the tumor.

Findings:

  • Complete surgical excision of the astroblastoma was achieved.
  • The patient showed no evidence of tumor recurrence at a 20-month follow-up.
  • This case demonstrates a favorable outcome following surgical management.

Implications:

  • This case highlights the potential for successful surgical management of pediatric astroblastoma.
  • Further research is needed to establish definitive WHO grading and treatment protocols.
  • Early diagnosis and complete resection appear critical for favorable prognosis in astroblastoma.