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Mutations in human αA-crystallin/sHSP affect subunit exchange interaction with αB-crystallin

Ilangovan Raju1, Lalita Oonthonpan, Edathara C Abraham

  • 1Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

Plos One
|February 21, 2012
PubMed
Summary

Mutations in alphaA-crystallin impair its interaction with alphaB-crystallin, potentially causing congenital cataracts. This study quantifies these interactions using FRET, revealing reduced subunit exchange and binding for specific alphaA-crystallin mutants.

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