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Published on: December 1, 2013
Vitamin e reduces superficial bladder cancer recurrence: a randomized controlled trial.
1Department of Urology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
International Journal of Preventive Medicine
|February 21, 2012
Summary
Vitamin E supplementation may reduce the recurrence of superficial bladder cancer. This effect was particularly noted in smokers, suggesting a potential role for antioxidants in managing bladder cancer risk.
Area of Science:
- Oncology
- Nutritional Science
- Urology
Background:
- Superficial bladder cancer frequently recurs after transurethral resection.
- Antioxidants and vitamins are being investigated for their potential to reduce cancer recurrence.
- This study focuses on vitamin E's effect on non-invasive bladder cancer recurrence.
Purpose of the Study:
- To investigate the impact of vitamin E intake on the recurrence rate of non-invasive bladder cancer.
Main Methods:
- A randomized controlled trial involving 46 patients with single, low-grade, superficial bladder tumors.
- Patients were assigned to either daily vitamin E (400 IU) or no vitamin E supplementation.
- Recurrence was monitored via ultrasound and urinalysis every three months.
Main Results:
- Vitamin E intake showed a trend towards decreased bladder cancer recurrence (19% vs. 36% in controls, P=0.04).
- The recurrence rate reduction was more pronounced in smokers.
- Most recurrences in both groups occurred within the first year.
Conclusions:
- Vitamin E supplementation significantly decreased bladder cancer recurrence.
- The benefit of vitamin E was particularly evident in smokers, potentially due to its antioxidant properties.
- Further research may explore vitamin E's role in managing bladder cancer, especially in high-oxidant states.
