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Focus on vitamin D, inflammation and type 2 diabetes
Carlos Eduardo Andrade Chagas1, Maria Carolina Borges, Lígia Araújo Martini
1Center for Nutrition Practice and Research, Department of Education, Institute of Biosciences, São Paulo State University, Botucatu, SP 18618-970, Brazil. cchagas@ibb.unesp.br
Nutrients
|February 21, 2012
Summary
Vitamin D may influence type 2 diabetes by affecting insulin secretion and sensitivity, with a secondary role in modulating inflammation. Further research is needed to confirm the link between vitamin D, inflammation, and type 2 diabetes.
Area of Science:
- Endocrinology
- Nutritional Science
- Metabolic Disorders
Background:
- Seasonal variations in glycemic control suggest a link between vitamin D and type 2 diabetes.
- Vitamin D status is implicated in pathways crucial for type 2 diabetes development.
- Inflammation disrupts metabolism and insulin signaling, potentially influenced by vitamin D.
Purpose of the Study:
- To explore the hypothesis that vitamin D influences glucose homeostasis by modulating inflammatory responses.
- To review existing human studies on vitamin D supplementation, inflammatory biomarkers, and type 2 diabetes risk.
Main Methods:
- Analysis of clinical and epidemiological data.
- Review of human studies investigating vitamin D supplementation effects on inflammatory biomarkers.
Main Results:
- Conflicting results exist regarding vitamin D supplementation's impact on inflammatory biomarkers.
- Positive effects of vitamin D appear primarily linked to insulin secretion and sensitivity.
- Secondary effects of vitamin D may involve modulation of inflammation.
Conclusions:
- Vitamin D's role in type 2 diabetes is likely multifaceted, affecting insulin dynamics and inflammation.
- More targeted research is required to establish a definitive connection between vitamin D, inflammation, and type 2 diabetes.
- Future studies should prioritize inflammation as a key outcome to elucidate vitamin D's role.
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