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Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the
Kuniyuki Onuma1, Eiichi Ishikawa, Masahide Matsuda
1Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Background:
The authors report a case of intraparenchymal germinoma pathologically diagnosed using navigation-guided endoscopic biopsy.
Case Description:
A 27-year-old man had mild left hemiparesis, transcortical motor aphasia, and amnesia. Magnetic resonance (MR) imaging revealed an intraparenchymal mass lesion near the left ventricular trigone. Navigation-guided endoscopic biopsy was performed, and histopathology revealed large neoplastic cells immunohistochemically positive for germinoma-specific antigens, which were diagnosed as pure germinoma. Chemotherapy with whole-brain radiotherapy was performed, and the neurological symptoms did not change during the treatment. Follow-up MR imaging 1 year after the surgery showed no evidence of recurrence or dissemination.
Conclusions:
Navigation-guided endoscopic biopsy can be a useful technique in such intraparenchymal germinoma cases.
