Functional imaging in muscular diseases

OBJECTIVE: The development of morphological and functional imaging techniques has improved the diagnosis of muscular disorders. METHODS: With the use of whole-body magnetic resonance imaging (MRI) the possibility of imaging the entire body has been introduced. In patients with suspected myositis, oedematous and inflammatory changed muscles can be sufficiently depicted and therefore biopsies become more precise. RESULTS: Functional MR methods visualise different aspects of muscular (patho)physiology: muscular sodium (Na(+)) homeostasis can be monitored with (23)Na MRI; the muscular energy and lipid metabolism can be monitored using (31)P and (1)H MR spectroscopy. (23)Na MRI has reached an acceptable value in the diagnosis and follow-up of patients with muscular Na(+) channelopathies that are characterised by myocellular Na(+) overload and consecutive muscle weakness. Besides MRI, low mechanical index contrast-enhanced ultrasound (CEUS) methods have also been introduced. For evaluation of myositis, CEUS is more efficient in the diagnostic work-up than usual b-mode ultrasound, because CEUS can detect the inflammatory-induced muscular hyperperfusion in acute myositis. Moreover, the arterial perfusion reserve in peripheral arterial disease can be adequately examined using CEUS. CONCLUSION: Modern muscular imaging techniques offer deeper insights in muscular (patho)physiology than just illustrating unspecific myopathic manifestations like oedematous or lipomatous changes, hypertrophy or atrophy.