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Updated: May 24, 2026

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

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Published on: April 17, 2017

Exogenous ether lipids predominantly target mitochondria.

Lars Kuerschner1, Doris Richter, Hans Kristian Hannibal-Bach

  • 1Life and Medical Sciences Institute, LIMES, University of Bonn, Bonn, Germany. lars.kuerschner@uni-bonn.de

Plos One
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Ether lipids accumulate in mitochondria and endoplasmic reticulum. The anti-cancer ether lipid edelfosine targets mitochondria, inducing apoptosis, suggesting mitochondria

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Mitochondria-associated ER Membranes (MAMs) and Glycosphingolipid Enriched Microdomains (GEMs): Isolation from Mouse Brain
10:32

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Published on: March 4, 2013

Area of Science:

  • Cell Biology
  • Lipid Metabolism
  • Mitochondrial Function

Background:

  • Ether lipids are essential membrane components with unknown functions.
  • Understanding ether lipid distribution and roles is crucial for cell biology.

Purpose of the Study:

  • To investigate the intracellular localization of ether lipids.
  • To explore the function of ether lipids in cellular processes.
  • To determine the mechanism of action for the anti-cancer ether lipid edelfosine.

Main Methods:

  • Utilized fluorescent polyene-ether lipids for microscopy-based intracellular distribution analysis.
  • Employed lyso-ether lipids as effective precursors for lipid tagging.
  • Observed morphological and apoptotic changes in cells treated with a fluorescent edelfosine analogue (Polyfosine).

Main Results:

  • Ether-phosphatidylcholine and ether-phosphatidylethanolamine were found to accumulate in mitochondria and endoplasmic reticulum.
  • Lyso-ether lipids proved to be superior precursors for specific lipid labeling.
  • Polyfosine accumulation in mitochondria correlated with induced cellular apoptosis and morphological alterations.

Conclusions:

  • Mitochondria play a significant role in ether lipid metabolism and trafficking.
  • Edelfosine's anti-cancer effects may stem from its ability to target and damage mitochondria, triggering apoptosis.
  • This study provides insights into the cellular functions of ether lipids and their potential therapeutic implications.