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Updated: May 24, 2026

Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry
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Imaging radiotherapy-induced apoptosis.

Adriana Haimovitz-Friedman1, Tzu-I Jonathan Yang, Tin Htwe Thin

  • 1Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. a-haimovitz-friedman@ski.mskcc.org

Radiation Research
|February 22, 2012
PubMed
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This summary is machine-generated.

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Predicting therapy response using in vivo apoptosis imaging helps personalize cancer treatment. This approach identifies patients who will benefit most from radiation, avoiding ineffective and toxic regimens.

Area of Science:

  • Oncology
  • Radiotherapy
  • Medical Imaging

Background:

  • Personalized medicine requires accurate prediction of therapy response.
  • In vivo imaging offers novel markers for treatment efficacy assessment.
  • Apoptosis imaging visualizes cell death, a key indicator of treatment response.

Purpose of the Study:

  • To review the role of in vivo apoptosis imaging as a predictive marker for tumor response to radiation.
  • To highlight advances in imaging techniques for cell death quantification.

Main Methods:

  • Review of current literature on in vivo apoptosis imaging techniques.
  • Focus on novel markers in anatomical and functional imaging.
  • Analysis of apoptosis imaging for predicting radiation therapy outcomes.

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One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
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Published on: October 23, 2017

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Last Updated: May 24, 2026

Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry
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Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry

Published on: September 1, 2019

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
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Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Published on: March 24, 2013

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
06:47

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy

Published on: October 23, 2017

Main Results:

  • In vivo apoptosis imaging enables visualization and quantification of cell death.
  • This imaging modality can serve as a predictive biomarker for treatment response.
  • Advances in imaging offer opportunities for customized cancer therapy.

Conclusions:

  • In vivo apoptosis imaging is a promising tool for predicting tumor response to radiation.
  • It facilitates personalized treatment selection, optimizing patient outcomes.
  • Further development in imaging markers can enhance predictive accuracy.