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Updated: May 24, 2026
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A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood
Published on: January 9, 2018
NMDA receptors in immune competent cells
A A Boldyrev1, E A Bryushkova, E A Vladychenskaya
1International Biotechnological Center, Lomonosov Moscow State University, Russia. aaboldyrev@mail.ru
Biochemistry. Biokhimiia
|February 22, 2012
Summary
NMDA-type glutamate receptors are found in immune cells like lymphocytes. Homocysteine may overactivate these receptors, contributing to toxicity and impacting immune function.
Area of Science:
- Neuroimmunology
- Molecular Immunology
Background:
- NMDA-type glutamate receptors are primarily known for their role in the central nervous system.
- Emerging evidence suggests their presence and function in peripheral immune cells.
Purpose of the Study:
- To review and analyze literature data on NMDA-type glutamate receptors in immune cells.
- To discuss the potential role of these receptors in immune cell function and modulation.
- To explore the interaction of these receptors with blood-circulating ligands, including homocysteine.
Main Methods:
- Literature review and analysis of existing scientific data.
- Examination of studies investigating NMDA receptor expression in thymocytes, lymphocytes, and neutrophils.
- Synthesis of information regarding ligand interactions and functional consequences.
Main Results:
- NMDA-type glutamate receptors are present in various immune-competent cells, including thymocytes, lymphocytes, and neutrophils.
- These receptors may play a significant role in modulating immune cell functions.
- Homocysteine is identified as a potential modulator of these receptors.
Conclusions:
- The presence and activity of NMDA-type glutamate receptors in immune cells represent a novel area in neuroimmunology.
- Homocysteine's interaction with these receptors, leading to hyperactivation, may explain its toxicity and influence on immune responses.
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