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Updated: May 24, 2026

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Published on: July 3, 2025

Mycobacterium avium-triggered diseases: pathogenomics.

Dmitriy Ignatov¹, Elena Kondratieva, Tatyana Azhikina

¹Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.

Cellular Microbiology

|February 22, 2012

Summary

Mycobacterium avium comprises diverse subspecies, including human pathogen Mycobacterium avium hominissuis (MAH). This review explores MAH

Area of Science:

Microbiology
Genomics
Pathogenesis

Background:

Mycobacterium avium comprises diverse subspecies with varied ecological niches and pathogenicity.
Recent genomic data illuminate phylogenetic relationships and niche adaptation within M. avium.
Mycobacterium avium hominissuis (MAH) is a significant opportunistic pathogen in immunocompromised individuals.

Purpose of the Study:

To review the genetic composition of M. avium subspecies.
To discuss the genetic and molecular basis of MAH-triggered disease pathogenesis.
To explore virulence, host-pathogen interactions, and host genetic control in MAH infections.

Main Methods:

Literature review of genomic and molecular studies on M. avium.
Analysis of genetic diversity and phylogenetic relationships.

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Examination of virulence factors and host immune responses.

Main Results:

Genomic diversity explains niche adaptation in M. avium.
Specific genetic features contribute to MAH pathogenicity.
MAH employs strategies for immune evasion and host cell penetration.

Conclusions:

Understanding M. avium genomics is crucial for deciphering niche adaptation.
MAH pathogenesis involves complex genetic and molecular mechanisms.
Host genetic factors play a role in susceptibility to MAH infections.