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Updated: May 24, 2026
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Poorly differentiated oncocytic thyroid carcinoma--diagnostic implications and outcome
Matthias Dettmer1, Anja Schmitt, Hans Steinert
1Institute of Pathology, University of Bern, Bern, Switzerland.
Histopathology
|February 22, 2012
Summary
The Turin criteria can diagnose oncocytic poorly differentiated thyroid carcinoma (PDTC). Oncocytic PDTC patients have worse survival outcomes than conventional PDTC, suggesting a need for new treatments.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Poorly differentiated thyroid carcinomas (PDTC) present diagnostic challenges.
- The Turin criteria for PDTC diagnosis initially excluded oncocytic tumors.
- The World Health Organization (WHO) classification includes an oncocytic variant of PDTC.
Purpose of the Study:
- To assess the applicability of Turin criteria to oncocytic PDTC.
- To investigate prognostic differences between conventional and oncocytic PDTC.
Main Methods:
- Application of Turin criteria to 129 thyroid carcinomas.
- Identification of 18 oncocytic PDTC and 16 conventional PDTC.
- Kaplan-Meier and multivariate analyses for survival outcomes.
Main Results:
- The Turin criteria were applicable to oncocytic PDTC.
- Oncocytic PDTC showed significantly worse overall and tumor-specific survival.
- No difference in relapse-free survival was observed between the groups.
- Survival was not associated with gender, age, or tumor stage.
Conclusions:
- The Turin criteria can be successfully applied to oncocytic PDTC.
- Oncocytic PDTC patients exhibit decreased survival with standard radioiodine treatment.
- These patients may benefit from novel therapeutic strategies.
