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08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Antioxidant pharmacological therapies for COPD
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA. irfan_rahman@urmc.rochester.edu
Current Opinion in Pharmacology
|February 22, 2012
Summary
Targeting oxidative stress in COPD with antioxidants may offer therapeutic benefits. This review discusses enhancing lung antioxidants and their potential positive effects on COPD progression.
Area of Science:
- Pulmonary Medicine
- Biochemistry
Background:
- Oxidative stress in the lungs and systemically is a key factor in Chronic Obstructive Pulmonary Disease (COPD) pathogenesis.
- Therapeutic strategies targeting oxidative stress are being explored for COPD management.
Purpose of the Study:
- To review approaches for enhancing lung antioxidants in COPD.
- To discuss the potential benefits of antioxidant therapy in COPD.
Main Methods:
- Review of existing literature on thiol antioxidants (e.g., N-acetyl-l-cysteine) and synthetic molecules (e.g., spin traps, catalytic antioxidants).
- Analysis of preclinical and clinical trial data on antioxidant effects on oxidative stress, gene expression, and inflammation.
Main Results:
- Thiol antioxidants increase lung thiol content.
- Synthetic antioxidants modulate cigarette smoke-induced oxidative stress and cellular changes.
- Antioxidants have shown potential in reducing oxidative stress and affecting gene expression related to redox balance and inflammation.
Conclusions:
- Enhancing lung antioxidants is a promising therapeutic avenue for COPD.
- Antioxidant therapy may positively influence the course of COPD by mitigating oxidative damage and inflammation.
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