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Updated: May 24, 2026
11:53
Cecal Ligation Puncture Procedure
Published on: May 7, 2011
Recommendations for sepsis management in resource-limited settings
Martin W Dünser1, Emir Festic, Arjen Dondorp
1Department of Anesthesiology, Perioperative and General Critical Care Medicine, Salzburg General Hospital and Paracelsus Private Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, Austria. M.Duenser@salk.at
Intensive Care Medicine
|February 22, 2012
Summary
This study offers a sepsis management framework for resource-limited settings, detailing acute and post-acute interventions for pediatric and adult patients. The recommendations aim to improve sepsis care where evidence is scarce.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Global Health
Background:
- Sepsis diagnosis and treatment are challenging in resource-limited settings.
- Limited clinical evidence exists for managing sepsis in low- and middle-income countries.
Purpose of the Study:
- To provide a framework for clinicians to improve sepsis diagnosis and treatment in resource-limited environments.
- To offer evidence-based recommendations for pediatric and adult sepsis management.
Main Methods:
- Systematic review of medical literature on sepsis management.
- Focused identification of clinical evidence from resource-limited settings.
Main Results:
- Recommendations encompass acute interventions: fluid resuscitation, vasopressors, corticosteroids, oxygen, ventilation, timely antimicrobials, source control, and microbiological work-up.
- Post-acute interventions include antimicrobial reassessment, hypoglycemia avoidance, DVT prophylaxis, early mobilization, and weaning of support.
- Specific guidance is provided for sepsis in malaria, puerperal sepsis, and HIV/AIDS patients.
Conclusions:
- A significant gap in evidence for sepsis management in resource-limited settings was identified.
- The proposed recommendations can enhance sepsis care in low- and middle-income countries.
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