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Updated: May 24, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
A review on various targeted anticancer therapies
Junjie Li1, Feng Chen, Marlein Miranda Cona
1Section of Radiology, Department of Diagnostic Sciences, Faculty of Medicine, University of Leuven, Herestraat 49, BE-3000, Leuven, Belgium.
This study reviews targeted anticancer therapies (TAT) and introduces a novel small molecular sequential dual targeting theragnostic strategy. This approach aims to improve the treatment and curability of solid malignancies with minimized side effects.
Area of Science:
- Oncology
- Translational Medicine
- Pharmacology
Background:
- Targeted anticancer therapy (TAT) offers a personalized medicine approach distinct from conventional treatments.
- TAT utilizes drugs with specific mechanisms to target cancer pathways, minimizing harm to healthy tissues.
- Existing TAT approaches show promise for clinical applications in oncology.
Purpose of the Study:
- To review current promising targeted anticancer therapy (TAT) approaches.
- To introduce a novel small molecular sequential dual targeting theragnostic strategy for solid tumors.
- To enhance cancer treatability and curability through advanced therapeutic strategies.
Main Methods:
- Review of existing literature on targeted anticancer therapies.
- Development and conceptualization of a novel small molecular sequential dual targeting theragnostic strategy.
- Discussion of the potential application of this strategy in managing solid malignancies.
Main Results:
- Identified promising TAT approaches for personalized cancer medicine.
- Proposed a new generalized class of TAT: small molecular sequential dual targeting theragnostic strategy.
- Highlighted the potential for improved cancer treatability and curability.
Conclusions:
- Targeted anticancer therapies represent a significant advancement in oncology.
- The newly developed sequential dual targeting theragnostic strategy offers a promising generalized approach for solid tumors.
- Further optimization of this strategy is expected to improve patient outcomes in cancer management.
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