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Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Genomic methods for clinical and translational pain research
Dan Wang1, Hyungsuk Kim, Xiao-Min Wang
1National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
None:
Pain is a complex sensory experience for which the molecular mechanisms are yet to be fully elucidated. Individual differences in pain sensitivity are mediated by a complex network of multiple gene polymorphisms, physiological and psychological processes, and environmental factors. Here, we present the methods for applying unbiased molecular-genetic approaches, genome-wide association study (GWAS), and global gene expression analysis, to help better understand the molecular basis of pain sensitivity in humans and variable responses to analgesic drugs.
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