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Related Experiment Video

Updated: May 24, 2026

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
07:39

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay

Published on: July 26, 2022

Orofacial pain models and behavior assessment.

Timothy K Y Kaan1, Peter T Ohara, Luc Jasmin

  • 1Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 22, 2012
PubMed
Summary
This summary is machine-generated.

Orofacial pain is understudied, with research focusing on the spine. This chapter presents animal models and behavior tests for orofacial pain, crucial for developing human therapies.

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Area of Science:

  • Neuroscience
  • Pain Research
  • Animal Models

Background:

  • Orofacial pain research is limited compared to spinal pain.
  • Understanding orofacial pain mechanisms is critical for effective treatment.

Purpose of the Study:

  • To present animal models of neuropathic and inflammatory orofacial pain.
  • To describe pain behavior tests for assessing orofacial pain.
  • To highlight the need for combined models and assessments for human orofacial pain therapy.

Main Methods:

  • Presentation of established animal models for orofacial pain.
  • Description of four distinct pain behavior tests.
  • Assessment of evoked, spontaneous, and conditional reward behaviors.

Main Results:

  • Animal models for neuropathic and inflammatory orofacial pain are detailed.
  • Specific behavioral tests are outlined for pain assessment.
  • The necessity of integrated approaches is emphasized.

Conclusions:

  • A combination of diverse pain models and behavioral assessments is essential.
  • This integrated approach will advance the understanding of human orofacial pain.
  • Effective therapeutic strategies for orofacial pain can be developed through this research.