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Updated: May 24, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
Rat models of pancreatitis pain
Karin N Westlund1, Louis Vera-Portocarrero
1Department of Physiology, Chandler Medical Center, University of Kentucky, Lexington, KY, USA. Karin.High@uky.edu
Abstract:
Pancreatic pain is often severe and difficult to treat clinically. Many animal models that mimic pancreatic pain are typically short term and invasive in nature. The present chapter describes the development and characterization of two non-invasive rat models of pancreatitis, one acute and one chronic. The two models described here are simple to replicate, giving them advantage over other animal models of pancreatic inflammation. A goal of this chapter is also to detail their usefulness as visceral pain models.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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