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Aging

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Related Experiment Video

Updated: May 24, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

Understanding aging.

¹Agoura, CA.

Methods in Molecular Medicine

|February 22, 2012

Summary

This summary is machine-generated.

Scientific understanding of aging has advanced significantly. Early key contributions include Weismann, Cowdry, Pearl, and Carrel, shaping the study of lifespan and cellular aging.

Related Experiment Videos

Last Updated: May 24, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

Area of Science:

Gerontology and Evolutionary Biology
Cellular Biology and Aging

Background:

Significant progress in understanding human aging has been made over the last 50 years.
Early foundational works from the late 19th to mid-20th centuries provided crucial insights into aging processes.

Purpose of the Study:

To review and highlight seminal contributions to the study of aging from the late 19th to mid-20th centuries.
To contextualize current understanding of aging within its historical scientific framework.

Main Methods:

Review of historical scientific literature, including books and essay collections.
Analysis of key theories proposed by prominent researchers in the field of aging.

Main Results:

August Weismann emphasized the role of natural selection and species advantage in determining lifespan.
Cowdry's 'Problems of Aging' (1938) offered a comprehensive collection of contemporary research.
Raymond Pearl linked aging to cell specialization, positing germ line resistance.
Alexis Carrel's work suggested indefinite cell culture viability, a claim that faced scientific debate.

Conclusions:

These early works established critical concepts and debates in aging research.
The historical perspectives underscore the evolutionary and cellular underpinnings of aging.