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Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Updated: May 24, 2026

A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity
06:08

A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity

Published on: August 9, 2017

Age-related alterations to natural killer cell function.

E Mariani1, C Alonso, R Solana

  • 1Istituto di Ricerca Codivilla Putti, Laboratorio di Immunologia e Genetica, Bologna, Italy.

Methods in Molecular Medicine
|February 22, 2012
PubMed
Summary
This summary is machine-generated.

Human natural killer (NK) cells are key immune cells that identify and destroy abnormal cells. Researchers use CD16 and CD56 markers to study how NK cell numbers change with age.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Human natural killer (NK) cells are crucial for innate immunity, targeting tumor and virally infected cells.
  • NK cells are immunophenotypically defined by CD16 (FcγRIIIA) and/or CD56 expression.
  • Unlike T and B cells, NK cells do not rearrange immunoglobulin (Ig) or T-cell receptor (TCR) genes, lacking surface Ig or TCR-CD3 complex expression (except for the zeta chain).

Purpose of the Study:

  • To investigate the role of CD16 and CD56 markers in analyzing age-associated alterations in NK cell populations.

Main Methods:

  • Immunophenotyping of natural killer (NK) cells using CD16 and CD56 surface markers.
  • Analysis of age-related variations in NK cell counts and distribution.

Main Results:

  • CD16 and CD56 expression patterns were utilized to assess NK cell populations.
  • Age-associated changes in the number of NK cells were investigated using these markers.

Conclusions:

  • CD16 and CD56 serve as reliable markers for studying age-dependent changes in human natural killer (NK) cell populations.
  • Further research can leverage these markers to understand NK cell dynamics across the lifespan.