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Updated: May 24, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Immunogenetics and Life-Span : HLA.

D Middleton¹, M D Curran, F Williams

¹Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Northern Ireland.

Methods in Molecular Medicine

|February 22, 2012

Summary

This summary is machine-generated.

The Major Histocompatibility Complex (MHC) contains genes crucial for immune responses. While HLA gene variations are linked to diseases and infections, their role in human longevity remains unclear and requires further investigation.

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

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Last Updated: May 24, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

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Published on: September 6, 2017

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

Immunogenetics
Human Genetics
Molecular Biology

Background:

The Major Histocompatibility Complex (MHC) on chromosome 6 contains immune-related genes, including Human Leukocyte Antigens (HLA).
HLA class I and II molecules present antigens to T cells, playing a critical role in immune responses.
The MHC region is highly polymorphic and associated with various diseases, including autoimmune and infectious conditions.

Purpose of the Study:

To explore the potential genetic role of Human Leukocyte Antigen (HLA) identity in human longevity.
To review existing evidence regarding the association between MHC genes and lifespan.

Main Methods:

Review of existing literature on MHC genetics, immune function, and lifespan studies.
Analysis of associations between specific HLA types and longevity in human populations.
Comparison of human findings with data from animal models (e.g., mice) investigating MHC and lifespan.

Main Results:

The MHC region is the most polymorphic in the human genome, with HLA genes crucial for immune function.
Specific HLA types are strongly associated with susceptibility or resistance to numerous diseases, particularly autoimmune and infectious diseases.
Current evidence linking HLA or MHC genes to human longevity is inconsistent and contradictory, with no definitive association established.

Conclusions:

The extreme polymorphism of HLA genes suggests a significant role in immune system adaptation and disease association.
Despite the established role of HLA in immunity and disease, its direct impact on human lifespan remains an open question.
Further research is needed to clarify the complex relationship between MHC genetics and human longevity.