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Updated: May 24, 2026
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data
1Department of Pediatrics, Mount Sinai Hospital, Toronto, Canada.
Pediatrics
|February 22, 2012
Summary
Recent blood transfusions are linked to necrotizing enterocolitis (NEC) in newborns. Infants with transfusion-associated NEC face higher mortality risks, underscoring the need for further research.
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
- Clinical Research
Background:
- Emerging evidence suggests a correlation between blood transfusions and necrotizing enterocolitis (NEC) in neonates.
- Understanding this association is crucial for improving infant outcomes.
Purpose of the Study:
- To systematically review and meta-analyze the association between transfusion and NEC (TANEC).
- To identify predictors of TANEC.
- To assess the impact of TANEC on neonatal outcomes.
Main Methods:
- Comprehensive literature search of Medline, Embase, CINAHL, and bibliographies.
- Independent data collection and quality assessment by two reviewers.
- Random effects model meta-analysis to calculate odds ratios and 95% confidence intervals.
Main Results:
- Eleven retrospective case-control studies and one cohort study were included.
- Recent transfusion exposure was significantly associated with NEC.
- TANEC infants were younger, had lower birth weight, and higher rates of PDA and ventilatory support, with increased mortality risk.
Conclusions:
- A significant association exists between recent transfusion and NEC in neonates.
- TANEC is linked to higher mortality, necessitating further investigation with confounder adjustment.
