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Updated: May 24, 2026
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Chromatin modification and senescence
Giovanni Di Bernardo1, Marilena Cipollaro, Umberto Galderisi
1Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Napoli, Italy.
Current Pharmaceutical Design
|February 23, 2012
Summary
Cellular senescence, a key factor in aging, is triggered by various stresses including DNA damage and chromatin alterations. This review explores how chromatin modifiers impact cellular senescence and aging processes.
Area of Science:
- Cellular Biology
- Aging Research
- Epigenetics
Background:
- Cellular senescence, or decline, is a major contributor to the aging process.
- Stresses like DNA damage and chromatin organization changes can induce senescence.
- The role of chromatin perturbation in senescence has been historically underestimated.
Purpose of the Study:
- To review the impact of chromatin modifiers on cellular senescence.
- To highlight the significance of chromatin organization changes in aging.
- To discuss various types of chromatin modifiers involved in senescence.
Main Methods:
- Literature review focusing on cellular senescence and aging.
- Analysis of the role of chromatin modifiers in senescence.
- Discussion of ATP-dependent chromatin remodelling complexes, histone-modifying enzymes, and DNA methylation proteins.
Main Results:
- Cellular senescence is induced by various stressors, including macromolecule damage.
- Chromatin organization changes and gene-expression patterns are altered during aging in eukaryotes.
- Perturbations in chromatin modifier function are linked to aging-related cellular changes.
Conclusions:
- Chromatin modifiers play a crucial role in the senescence process.
- Understanding chromatin dynamics is essential for aging research.
- Further investigation into chromatin modifiers offers potential insights into age-related decline.
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