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NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
Fragment-based design of small RNA binders: promising developments and contribution of NMR
Roba Moumné1, Marjorie Catala, Valéry Larue
1CNRS, UMR 8638, Synthèse et structure de molécules d'intérêt pharmacologique, 4 avenue de l'Observatoire, 75006 Paris, France.
Biochimie
|February 23, 2012
Abstract:
Fragment-based drug design has become increasingly popular over the last decade. We review here the use of this approach to design small RNA binders. In addition, we discuss the use of NMR to detect the binding of small molecules on RNA targets and to guide chemists in the design of compounds targeting RNA.
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