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Updated: May 24, 2026
07:12
Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
Published on: September 9, 2021
Targeting the interleukin-6/Jak/stat pathway in human malignancies.
Pasquale Sansone1, Jacqueline Bromberg
1Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA.
Summary
The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway, particularly interleukin-6-mediated Stat3 activation, is crucial in cancer development and progression. Inhibitors targeting this pathway show promise for cancer treatment.
Area of Science:
- Molecular Biology
- Oncology
- Cell Signaling
Background:
- The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway mediates cytokine signaling.
- Over 2,500 articles highlight its role in malignancies.
- Interleukin-6 (IL-6)-mediated activation of Stat3 is a key pathway in tumorigenesis.
Purpose of the Study:
- To review the Jak/Stat pathway's role in nonmalignant and malignant conditions.
- To explore the influence of other Stats.
- To discuss Jak/Stat inhibitors for cancer therapy.
Main Methods:
- Literature review of published articles on the Jak/Stat pathway.
- Analysis of the role of Stat3 activation in cancer.
- Examination of current and potential Jak/Stat inhibitors.
Main Results:
- Stat3 regulates critical mediators of tumor formation and metastasis.
- The pathway is implicated in both tumor-intrinsic and extrinsic processes.
- IL-6/Stat3 signaling is a principal driver of tumorigenesis.
Conclusions:
- The Jak/Stat pathway, especially IL-6/Stat3, is vital in cancer.
- Understanding this pathway is key to developing targeted therapies.
- Jak/Stat inhibitors offer potential for cancer control and eradication.
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