Related Experiment Video
Updated: May 24, 2026

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
Molecular complexity determines the number of olfactory notes and the pleasantness of smells
F Kermen1, A Chakirian, C Sezille
1INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France; University of Lyon, F-69000, France.
Abstract:
One major unresolved problem in olfaction research is to relate the percept to the molecular structure of stimuli. The present study examined this issue and showed for the first time a quantitative structure-odor relationship in which the more structurally complex a monomolecular odorant, the more numerous the olfactory notes it evokes. Low-complexity odorants were also rated as more aversive, reflecting the fact that low molecular complexity may serve as a warning cue for the olfactory system. Taken together, these findings suggest that molecular complexity provides a framework to explain the subjective experience of smells.
More Related Videos
Related Concept Videos
Olfaction
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway
The olfactory...
Olfactory Receptors: Location and Structure
Molecular Shapes
Two regions of electron density in a diatomic...
Tactile and Chemical Senses
Gustation

