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Related Experiment Video

Updated: May 24, 2026

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

Published on: June 19, 2018

Vascular hyperpermeability, angiogenesis, and stroma generation.

Janice A Nagy¹, Ann M Dvorak, Harold F Dvorak

¹Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.

Cold Spring Harbor Perspectives in Medicine

|February 23, 2012

Summary

This summary is machine-generated.

Tumor blood vessels are leaky, allowing plasma proteins to enter tissues. This leakage initiates stroma formation, a critical step in tumor growth and progression.

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Area of Science:

Oncology
Vascular Biology
Biochemistry

Background:

Tumor microvasculature exhibits hyperpermeability to plasma proteins, a phenomenon known for decades.
The specific leaky vessels and consequences of this hyperpermeability remain underexplored.
This article contextualizes tumor vascular hyperpermeability within normal and pathological angiogenesis.

Purpose of the Study:

To review and contextualize the phenomenon of tumor vascular hyperpermeability.
To link vascular hyperpermeability to normal vascular function and pathological angiogenesis.
To highlight the role of plasma protein leakage in initiating tumor stroma generation.

Main Methods:

Literature review and synthesis of existing research on tumor vascular permeability.
Comparison of basal, acute, and chronic vascular hyperpermeability.
Analysis of the downstream effects of plasma protein extravasation.

Main Results:

Tumor vascular hyperpermeability is linked to basal, acute (e.g., VEGF-A induced), and chronic pathological states.
Leakage of plasma proteins activates the clotting system.
Extravascular fibrin gel deposition serves as the initial matrix for stroma generation.

Conclusions:

Tumor vascular hyperpermeability is a multifaceted process with significant implications for tumor biology.
The extravasation of plasma proteins is a key initiator of the tumor microenvironment's stroma.
Understanding this process is crucial for developing novel cancer therapies targeting tumor stroma.