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Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
A preliminary study on the FAM5C expression in generalized chronic periodontitis
F V Ribeiro1, V R Santos, M F Bastos
1Dental Research Division, School of Dentistry, Paulista University, São Paulo, Brazil.
Oral Diseases
|February 23, 2012
Summary
Family with sequence similarity 5 member C (FAM5C) did not show altered expression in chronic periodontitis. This study found no association between FAM5C and key inflammatory markers in periodontal disease.
Area of Science:
- Periodontal disease research
- Immunoinflammatory marker analysis
- Gene expression profiling
Background:
- Family with sequence similarity 5 member C (FAM5C) is implicated in aggressive periodontitis.
- The role of FAM5C in chronic periodontitis remains uninvestigated.
Purpose of the Study:
- To assess FAM5C gene expression in chronic periodontitis.
- To determine the association between FAM5C and key immunoinflammatory markers in periodontitis.
Main Methods:
- Gingival biopsies from healthy (n=10) and chronic periodontitis (n=15) subjects.
- Real-time PCR to quantify mRNA levels of FAM5C and various cytokines (IL-17, IL-6, IL-23, IL-10, IL-4, IFN-c), receptors (TLR-2, TLR-4, OPG, RANKL), and transcription factors (TNF-a, TGF-b, FOXP3, ORC2).
Main Results:
- FAM5C mRNA levels were comparable between healthy and chronic periodontitis tissues.
- Elevated expression of IL-17, TNF-a, OPG, RANKL, TLR-2, and TLR-4 was observed in periodontitis.
- No significant correlations were found between FAM5C gene expression and other evaluated immunoinflammatory markers.
Conclusions:
- FAM5C expression does not appear to play a significant role in the pathogenesis of chronic periodontitis.
- Further research may be needed to fully elucidate the function of FAM5C in periodontal health and disease.