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Updated: May 24, 2026

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major
Mahmoodi Nesheli Hassan1, Galini Moghaddam Tahereb, Tamaddoni Ahmad
1Department of Pediatric Hematology & Oncology, Babol University of Medical Sciences, Babol, Iran.
Objective:
To evaluate the correlation of portal vein thrombosis and splenectomy in beta-thalassemia major patients visiting Babol Medical University, Iran.
Methods:
This cohort study was done from 1997 to 2008. In our study, major beta-thalassemic patients visiting for transfusion at least once a month at Amirkola Children's Hospital were selected. Portal vein thrombosis was diagnosed through Doppler ultrasound in symptomatic patients. Cases were 160 beta-thalassemia major patients who underwent splenectomy and 160 remaining thalassemic patients without splenectomy were controls. Statistical comparison with Fisher exact test was performed.
Results:
Five cases had suffered from portal vein thrombosis (P = 0.03). Majority patients with portal vein thrombosis had their symptoms after first month of the operation.
Conclusion:
Correlation of splenectomy with portal vein thrombosis is statistically significant among beta-thalassemic children from Iran.
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