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Updated: May 24, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
Published on: June 25, 2018
A general preparation of protected phosphoamino acids
Daniel E Petrillo1, Dale R Mowrey, Shawn P Allwein
1Chemical Process Research and Development, Cephalon Inc., 383 Phoenixville Pike, Malvern, Pennsylvania 19355, USA. dpetrill@cephalon.com
Abstract:
Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
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