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Updated: May 24, 2026

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity
Published on: November 16, 2017
Potent norovirus inhibitors based on the acyclic sulfamide scaffold
Dengfeng Dou1, Kok-Chuan Tiew, Sivakoteswara Rao Mandadapu
1Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
Abstract:
The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility. These compounds are suitable for further optimization of pharmacological and ADMET properties.
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