Related Experiment Videos
Somatostatin inhibits neutrophil elastase release in vitro
E O Adeyemi1, A P Savage, S R Bloom
1Department of Medicine, Royla Postgraduate Medical School, Hammersmith Hospital, London.
Peptides
|July 1, 1990
Abstract:
The influence of the long-acting somatostatin analogue, SMS 201-995, on FMLP-induced neutrophil elastase release in vitro has been investigated. Doses from 150 ng/ml upwards inhibited elastase release, with 100% inhibition by 2500 ng/ml. Inhibition was demonstrated both by an assay measuring elastase immunometrically and by an assay based on its enzyme activity. The demonstration that SMS 201-995 inhibits protease release from polymorphonuclear leukocytes may have implications for the long-term clinical use of this somatostatin analogue.