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Experimental prostatitis in nonhuman primates: I. Bacterial adherence in the urethra
J P Dilworth1, D E Neal, E N Fussell
1Department of Urology, Delta Regional Primate Research Center, Covington, Louisiana 70433.
The Prostate
|January 1, 1990
Summary
Male monkeys share urothelial receptors with humans for E. coli P-fimbriae. This makes them a suitable model for studying ascending prostatitis infections in men.
Area of Science:
- Microbiology
- Urology
- Comparative Anatomy
Background:
- Escherichia coli P-fimbriae are known to adhere to urothelial cells.
- The male urethra possesses unique pseudostratified columnar cells.
Purpose of the Study:
- To investigate the adherence of P-fimbriae to the male monkey urethra.
- To evaluate the monkey as a model for studying ascending urinary tract infections.
Main Methods:
- Scanning electron microscopy was used to visualize bacterial adherence.
- Adherence assays were performed on urothelial cells from both humans and monkeys.
Main Results:
- Both human and monkey urothelial cells exhibit receptors for P-fimbriae.
- P-fimbriae were identified as the primary mediators of adherence to male urethral cells in monkeys.
- Scanning electron microscopy confirmed P-fimbriae adherence to monkey urethral cells.
Conclusions:
- The male monkey serves as a relevant model for studying the ascending route of prostatitis.
- Understanding P-fimbriae adherence is crucial for developing treatments for male urinary tract infections.