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Related Concept Videos

Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Related Experiment Video

Updated: May 24, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Bone matters in lung cancer.

T Brodowicz1, K O'Byrne2, C Manegold3

  • 1Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna General Hospital, Vienna, Austria.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|February 24, 2012
PubMed
Summary

Bone metastases significantly impact advanced lung cancer patients. Bone-targeted therapies like denosumab help prevent skeletal-related events (SREs) and improve quality of life (QoL).

Related Experiment Videos

Last Updated: May 24, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Area of Science:

  • Oncology
  • Bone Metastases Research

Background:

  • Bone metastases represent a significant clinical challenge in advanced lung cancer.
  • These metastases are often undertreated, leading to substantial patient burden and healthcare costs.

Purpose of the Study:

  • To review the incidence of bone metastases and skeletal-related events (SREs) in lung cancer patients.
  • To examine the impact of these events on patients and healthcare systems.
  • To investigate available therapies for improving survival and quality of life (QoL).

Main Methods:

  • Literature review of bone metastases and SREs in lung cancer.
  • Analysis of patient burden and healthcare system costs.
  • Investigation of therapeutic interventions for SREs and QoL.

Main Results:

  • Bone metastases are common in lung cancer, but SRE data is limited due to short survival.
  • Skeletal-related events incur substantial treatment costs.
  • Bisphosphonates reduce SREs and improve QoL but carry risks like nephrotoxicity.
  • Denosumab shows superiority over zoledronic acid in delaying the first SRE in solid tumors, including lung cancer.

Conclusions:

  • Bone-targeted therapies are crucial for managing lung cancer patients with bone metastases.
  • These therapies aim to delay disease progression and preserve patients' quality of life.
  • Increased awareness of SRE consequences will likely expand the role of bone-targeted treatments.