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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Video

Updated: May 24, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

[Relationship between TIM-4 polymorphism and childhood asthma].

Jian-Ping Chen¹, Wan-Ying Zhao, Nian-Hai He

¹Department of Pediatrics, Southwest Hospital, Third Military Medical University, Chongqing, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics

|February 24, 2012

Summary

Genetic variations in the T-cell immunoglobulin and mucin domain-containing protein 4 (TIM-4) gene, specifically at the RS4704727 locus, are linked to childhood allergic asthma risk in Southwest China. This finding offers insights into asthma pathogenesis.

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Last Updated: May 24, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Published on: June 4, 2017

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Area of Science:

Genetics
Immunology
Pediatrics

Context:

Childhood allergic asthma is a significant public health concern, particularly in specific geographic regions.
The genetic underpinnings of asthma susceptibility are complex and may involve immune-regulating genes.
Understanding regional genetic predispositions is crucial for targeted prevention and treatment strategies.

Purpose:

To investigate the association between polymorphisms in the asthma immune regulator gene TIM-4 (T-cell immunoglobulin and mucin domain-containing protein 4) and the risk of childhood allergic asthma.
To analyze specific single nucleotide polymorphisms (SNPs) RS6882076 and RS4704727 within the TIM-4 gene.
To evaluate these genetic variations in a case-control study population from Southwest China.

Summary:

A case-control study involving 579 children with asthma and 524 controls was conducted.
Genotyping of TIM-4 gene promoter (RS6882076) and intron (RS4704727) polymorphisms was performed using PCR-RFLP.
Significant differences in genotype and allele frequencies at RS4704727 were observed between asthma cases and controls, with the T allele being less frequent in the asthma group (OR=1.603, P<0.01). No significant association was found for RS6882076.

Impact:

The RS4704727 polymorphism in the TIM-4 gene may contribute to the risk of developing childhood allergic asthma in the Southwest China population.
This research enhances the understanding of the genetic factors involved in the pathogenesis of childhood asthma.
Findings could inform future genetic screening and personalized medicine approaches for pediatric asthma in the region.