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Updated: May 24, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Biomedical mass spectrometry in today's and tomorrow's clinical microbiology laboratories
Alex van Belkum1, Martin Welker, Marcel Erhard
1bioMérieux SA, R&D Microbiology, La Balme Grottes, France. alex.vanbelkum@biomerieux.com
Abstract:
Clinical microbiology is a conservative laboratory exercise where base technologies introduced in the 19th century remained essentially unaltered. High-tech mass spectrometry (MS) has changed that. Within a few years following its adaptation to microbiological diagnostics, MS has been introduced, embraced, and broadly accepted by clinical microbiology laboratories throughout the world as an innovative tool for definitive bacterial species identification. Herein, we review the current state of the art with respect to this exciting new technology and discuss potential future applications.
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