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Fatal malformations in Jamaica.

K Coard1, C Escoffery, G Codrington

  • 1Department of Pathology, University of the West Indies, Kingston, Jamaica.

Pediatric Pathology
|January 1, 1990
PubMed
Summary

Major congenital malformations were identified in Jamaican infants, affecting multiple systems. Their impact on infant mortality is expected to rise as other causes decrease, highlighting the need for diagnostic services.

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Area of Science:

  • Pediatrics
  • Medical Genetics
  • Public Health

Background:

  • Major congenital malformations represent a significant concern in neonatal and perinatal health.
  • Understanding the prevalence and types of malformations is crucial for public health planning.

Purpose of the Study:

  • To identify and characterize major congenital malformations in perinatal and neonatal deaths in Jamaica.
  • To assess the contribution of malformations to infant mortality and inform service provision.

Main Methods:

  • Retrospective analysis of data from the Jamaica Perinatal Morbidity and Mortality Survey.
  • Inclusion of cases from both necropsy-examined and non-examined deaths.

Main Results:

  • Major malformations were detected in 8.6% of deaths with necropsy and 2.6% without.
  • Central nervous system, renal, gastrointestinal, and cardiovascular systems were most frequently affected.
  • Ten distinct malformation syndromes/sequences were identified, with many infants exhibiting multiple anomalies.

Conclusions:

  • Currently, major malformations are a minor cause of infant mortality in Jamaica but are projected to increase in significance.
  • The pattern of fatal malformations is vital for planning neonatal diagnostic and surgical services.
  • This data is essential for discussions regarding the provision of prenatal diagnostic services.

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