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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
Published on: February 23, 2020
Elevated plasma D-dimer and hypersensitive C-reactive protein levels may indicate aortic disorders.
Shi-Min Yuan1, Yong-Hui Shi, Jun-Jun Wang
1Department of Cardiothoracic Surgery, Afiliated Hospital, Taishan Medical College, Taian, Shandong Province, People's Republic of China. s.m.yuan@v.gg
Summary
Patients with acute aortic dissection and aortic aneurysm show significantly higher D-dimer and C-reactive protein levels compared to coronary artery disease patients. These biomarkers may aid in differentiating aortopathies from ischemic heart disease.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Diagnostic Tools
Background:
- D-dimer and C-reactive protein (CRP) are established biomarkers for thrombotic conditions.
- Their comparative diagnostic and predictive values in acute aortic dissection (AAD) versus coronary artery disease (CAD) remain insufficiently understood.
Purpose of the Study:
- To compare plasma D-dimer and hypersensitive C-reactive protein (hs-CRP) levels between patients with AAD, aortic aneurysm (AA), and CAD.
- To investigate the correlation between these biomarkers in different patient groups.
Main Methods:
- Plasma and aortic tissue samples were analyzed from patients undergoing surgery for AAD (n=20), AA (n=9), and CAD (n=20).
- D-dimer and hs-CRP levels were quantified using established laboratory assays.
Main Results:
- Significantly elevated plasma D-dimer and hs-CRP were observed in AAD and AA groups compared to CAD and healthy controls (P < 0.0001 for most comparisons).
- Strong positive correlations between plasma D-dimer and hs-CRP were found in AAD and AA groups (r > 0.67, P < 0.001).
- Aortic supernatant D-dimer and hs-CRP showed no significant inter-group differences, except for undetectable D-dimer in CAD patients.
Conclusions:
- Elevated plasma D-dimer and hs-CRP in AAD and AA suggest pronounced inflammatory responses and coagulopathies.
- These biomarkers may assist in the differential diagnosis of acute chest pain presentations, distinguishing aortopathies from ischemic heart disease.
- Tissue-based biomarker analysis showed limited clinical utility.
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