Related Experiment Video
Updated: May 24, 2026

Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
Published on: May 19, 2020
[Surveillance of resistance to antitubercular drugs in Cuba, 2000-2009]
Ernesto Montoro1, Dihadenys Lemus, Miguel Echemendia
1Laboratorio Nacional de Referencia e Investigaciones en Tuberculosis y Micobacterias, Centro Colaborador de la OPS/OMS, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba. emontoro@ipk.sld.cu
Objective:
Determine the prevalence of resistance to antitubercular drugs in Cuba in the 2000-2009 decade.
Methods:
A prospective longitudinal study was conducted. The sample group consisted of 2,285 Mycobacterium tuberculosis isolates obtained from throughout the country in the period from 1 January 2000 to 31 December 2009. The proportion method was used in Löwenstein-Jensen media with the first-line drugs: isoniazid, streptomycin, ethambutol, and rifampicin.
Results:
In the new cases and patients with a history of previous treatment, resistance was 8.5% and 37.0%, respectively. In these case categories, multidrug resistance was 0.4% and 8.8%, respectively.
Conclusions:
This study shows low prevalence of multidrug-resistant strains in Cuba. The results reflect the progress made by the national control program, which is currently working on the elimination of tuberculosis as a public health problem in the country.
Related Concept Videos
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Therapeutic Drug Monitoring: Affecting Factors
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Antimicrobial Effectiveness
Therapeutic Drug Monitoring: Drug Analysis Methods
Development of Antibiotic Resistance

