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Updated: May 24, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells
K Horiuchi1, H Tsurushima, B Soo Kim
1RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN) Institute of Applied Biochemistry, Japan.
Abstract:
Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on formalin-fixed autologous target tumor cells derived from glioblastoma multiforme. Growth response of the CTL restimulated with the fixed target cells was larger than those with live target cells. The results suggest that formalin-fixed tumor cells will be stable sources of tumor antigen for efficient autologous CTL expansion and be useful for adoptive immunotherapy of tumors.
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