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Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
Published on: November 6, 2017
Cerebellar neurones: Differentiation and modulation of sensitivity to excitotoxic treatment
D Mercanti1, A Angelini, M Ciotti
1Institute of Neurobiology, CNR, Viale Marx 15/43, 00137, Roma, Italy.
Cytotechnology
|February 24, 2012
Abstract:
The neurite outgrowth and adhesion complex (NOAC), isolated from rabbit sera has been dissociated in its major components by reverse-phase chromatography in HPLC by using a C(18) column. SDS-PAGE analisys of the active fractions revealed the presence of three major bands of approximately 100, 70 and 50 kDa. Studies on the biological activity of NOAC were carried out on rat cerebellar granule cells. NOAC-cultured cells exhibit a marked resistance to excitotoxic stimuli carried by glutamate.
