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In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
Published on: February 3, 2018
Use of cell cultures, nuclear and radioanalytical techniques for metallotoxicological studies at the JRC-Ispra
E Sabbioni1, G Pozzi, M Fischbach
1Environment Institute Joint Research Centre, Ispra Site, Commission of the European Communities, 21020, Ispra Varese, Italy.
Abstract:
This paper reviews the JRC-Ispra research activity on toxicological studies related to the environmental and occupational exposure of trace metals, as carried out by a combination of cell culture methodologies with nuclear and radioanalytical techniques.Applications concern the setting of uptake-effect relationships and the study of the mechanisms of toxicity of specific metals (Al, As, Cd, Co, Cr, Mo, Se, V), as well as the establishment of ranking of metal toxicity by carrying out systematic studies (screening tests).
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