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Updated: May 24, 2026

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
07:39

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

\4 integrin expression onin vitro andin vivo metastatic variants of lewis lung carcinoma

L Cimino1, D Perrotti, R Falcioni

  • 1Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Viale Regina Elena, 291, Rome, Italy.

Cytotechnology
|February 24, 2012
PubMed

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
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