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A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

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On the mode of action ofClostridium difficile toxin A: anin vitro study

C Fiorentini1, G Donelli, P Nicotera

  • 1Lab. Ultrastrutture, Istituto Superiore di Sanita', Viale Regina Elena 299, 00161, Roma, Italy.

Cytotechnology
|February 24, 2012
PubMed

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Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...